| Team | 1 | 2 | 3 | 4 | T |
|---|---|---|---|---|---|
| WagnWagner | 0 | 0 | 0 | 7 | 7 |
 Buffalohome | 14 | 24 | 21 | 10 | 69 (winner) |
Scoreboard · 2021
Week 1
Aug 28 – Sep 6 · 95 games · 95 final · ranks from the AP Preseason poll
20
Top-25 games
5
Ranked vs ranked
6
Upsets
Upset alert
Virginia Techover#10 North Carolina17-10
#19 Penn Stateover#12 Wisconsin16-10
#18 Iowaover#17 Indiana34-6
#5 Georgiaover#3 Clemson10-3- MontMontanaover#20 Washington13-7
UCLAover#16 LSU38-27
Thursday, September 2 · 2 games
| Team | 1 | 2 | 3 | 4 | T |
|---|---|---|---|---|---|
| LongLong Island University | 0 | 10 | 0 | 0 | 10 |
 Florida Internationalhome | 21 | 7 | 10 | 10 | 48 (winner) |
Friday, September 3 · 1 games
| Team | 1 | 2 | 3 | 4 | T |
|---|---|---|---|---|---|
| SainSaint Francis | 0 | 7 | 0 | 8 | 15 |
 Eastern Michiganhome | 14 | 14 | 7 | 0 | 35 (winner) |
Saturday, September 4 · 1 games
| Team | 1 | 2 | 3 | 4 | T |
|---|---|---|---|---|---|
| DuquDuquesne | 0 | 0 | 3 | 0 | 3 |
 TCUhome | 21 | 14 | 3 | 7 | 45 (winner) |
Rankings shown are from the 2021 AP Preseason poll, the one in force at kickoff.