| Team | 1 | 2 | 3 | 4 | T |
|---|---|---|---|---|---|
 Louisville | 14 | 21 | 13 | 14 | 62 (winner) |
 Dukehome | 3 | 6 | 7 | 6 | 22 |
Scoreboard · 2021
Week 12
Nov 16 – Nov 20 · 74 games · 74 final · ranks from the AP Week 12 poll
22
Top-25 games
3
Ranked vs ranked
2
Upsets
Upset alert
Clemsonover#13 Wake Forest48-27
#24 Utahover#4 Oregon38-7
Thursday, November 18 · 1 games
Saturday, November 20 · 7 games
| Team | 1 | 2 | 3 | 4 | T |
|---|---|---|---|---|---|
 Florida State | 7 | 12 | 7 | 0 | 26 (winner) |
 Boston Collegehome | 0 | 3 | 7 | 13 | 23 |
| Team | 1 | 2 | 3 | 4 | T |
|---|---|---|---|---|---|
 #13Wake Forest | 0 | 10 | 3 | 14 | 27 |
| Clemsonhome | 10 | 7 | 21 | 10 | 48 (winner) |
| Team | 1 | 2 | 3 | 4 | T |
|---|---|---|---|---|---|
| WoffWofford | 0 | 7 | 0 | 7 | 14 |
 North Carolinahome | 10 | 10 | 14 | 0 | 34 (winner) |
| Team | 1 | 2 | 3 | 4 | T |
|---|---|---|---|---|---|
 Georgia Tech | 0 | 0 | 0 | 0 | 0 |
 #6Notre Damehome | 24 | 21 | 10 | 0 | 55 (winner) |
| Team | 1 | 2 | 3 | 4 | T |
|---|---|---|---|---|---|
 Virginia | 7 | 14 | 10 | 7 | 38 |
 #20Pittsburghhome | 0 | 24 | 10 | 14 | 48 (winner) |
| Team | 1 | 2 | 3 | 4 | T |
|---|---|---|---|---|---|
 Syracuse | 0 | 7 | 3 | 7 | 17 |
 #25NC Statehome | 0 | 28 | 10 | 3 | 41 (winner) |
| Team | 1 | 2 | 3 | 4 | T |
|---|---|---|---|---|---|
 Virginia Tech | 3 | 10 | 13 | 0 | 26 |
 Miamihome | 14 | 14 | 3 | 7 | 38 (winner) |
Rankings shown are from the 2021 AP Week 12 poll, the one in force at kickoff.